Doctor Wolfgang Koller said on Friday that it took nearly 50 minutes to reanimate the prince, who is the second son of Queen Beatrix of the Netherlands.
MRI scans have showed his brain suffered "massive damage" in the avalanche in Lech on Feb. 17 in which he was buried for at last 15 minutes.
"It is clear that the oxygen starvation has caused massive brain damage to the patient," he said. "At the moment, it cannot be predicted if he will ever regain consciousness."
Prince Friso, 43, who is married and has two young daughters, will be moved at a later date to a private clinic for further treatment but it may take years before he awakens, if ever.
He was among a group of five skiers who went off-piste despite an avalanche warning of level four out of a maximum five in Lech, an upmarket town that is a popular destination with the Dutch royal family.